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Starfruit can be fatal when you have mild kidney problems

 
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JoeReal
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Joined: 16 Nov 2005
Posts: 4726
Location: Davis, California

Posted: Wed 31 Jan, 2007 9:14 pm

This could be old news but very credible. It has been published in credible medical journals. I was planning on making Starfruit wine, as it took best of show awards in Australia local wine contest, and already have the materials but then came across this old news article. I have no problem eating starfruit or carambola fruits when I was younger, but growing old, most problems come up like high cholesterol, diabetes which can lead to renal problems, and now this:

Starfruit, Averrhoa carambola


Star Fruit Warning

Eating Star Fruit May be Fatal in Uremic Patients
Westport 2-11-00 Reuters Health - Am J Kidney Dis 2000; 35: 189-193

Patients with renal failure, even those not yet undergoing dialysis, can develop severe and potentially fatal neurologic complications after eating star fruit.

Dr. Yung-Hsiung Lai and colleagues at Kaohsiung Medical University, in Kaohsiung, Taiwan, explain in the February issue of the American Journal of Kidney Diseases that "substances safely ingested by healthy persons can be deleterious for uremic patients." Because of its high potassium content, star fruit may be considered to be one such substance that uremic patients should exclude from their diets.

In a review of hospital records, Dr. Lai and colleagues identified 20 uremic patients with star fruit-related toxicity in the past 10 years, of whom eight died within 5 days of ingestion despite intensive medical care and emergency hemodialysis. One patient who died had a serum creatinine level of 6.4 mg/dL and had not yet begun dialysis.

"Their initial presentations included sudden-onset limb numbness, muscle weakness, intractable hiccups, consciousness disturbance of various degrees and seizure,"the researchers say. No clinical characteristics appeared to differentiate survivors from patients who died after star fruit ingestion, with the exceptions of consciousness disturbance and seizure on presentation.

Analysis of patients' blood biochemistry and the electrolyte concentrations of star fruit "eliminated the possibility that hyperkalemia was responsible for the syndrome,"according to the report. The authors also identified uremic patients from their records who had eaten star fruit but developed none of these manifestations, suggesting that host characteristics or different types or formulations of star fruit may affect clinical outcomes.

While nephrologists in Taiwan have been aware of the dangers of star fruit consumption by uremic patients for more than 10 years, the first formal report on this issue was published only 2 years ago. Based on their experience and past reports, Dr. Lai and colleagues "warn practicing nephrologists that star fruit intoxication must be considered when uremic patients present with consciousness disturbance or other unexplained neurological symptoms."



http://starbulletin.com/2003/04/28/features/health.html
Kidney patients
should avoid star fruit

Star fruit is a decorative and refreshing treat and, for most of us, a healthy delicacy. But for some people with impaired kidney function, the star fruit (also known as carambola) can be deadly.

Researchers from Brazil and Taiwan are studying why star fruit causes serious life-threatening reactions to some kidney patients.

Question: What are the symptoms of star fruit intoxication?

Answer: Typical symptoms occur within one to five hours and include persistent hiccups, nausea, vomiting, agitation, insomnia, mental confusion and convulsions. Death sometimes results. A study conducted at the University of Sao Paulo found that hiccups were experienced in 30 of 32 cases, and vomiting in about two-thirds. Even though mental confusion and convulsions were less common, these symptoms are more likely to be associated with death.

Q: Does star fruit cause kidney problems?

A: No. Star fruit intoxication only occurred if some degree of kidney failure already existed. For most of those affected, kidney decline was extensive enough that they were being treated by blood dialysis, although in four cases kidney problems had not reached that severity. There is no evidence of any problem for people with normal kidney function.

Q: What substance in star fruit causes this problem?

A: The tangy tartness in star fruit comes from high levels of oxalic acid (or oxalate). Weakened kidneys can be damaged if high levels of oxalate accumulate in the organ. But it is likely that another toxin in star fruit is also problematic since common foods such as spinach contain even greater levels of oxalic acid and do not seem to be associated with this severe problem.

The Brazilian researchers think that star fruit contains a substance toxic to nerves (a neurotoxin). People with healthy kidneys probably clear this toxin from the blood quickly and experience no problem. Without efficient kidney function, the combined effect of oxalate and a neurotoxin may deliver a double whammy.

Q: How much star fruit needs to be consumed to produce toxic effects in kidney patients?

A: As little as one half of a fruit and less than eight ounces of star fruit juice has caused serious symptoms. One person died from eating just one fruit.

Current medical treatment for star fruit intoxication is prompt kidney dialysis. Anyone who experiences hiccups, vomiting or other unusual symptoms after eating star fruit should seek medical attention as soon as possible.

On the positive side, star fruit lovers with normal kidneys should be able to continue enjoying the delectable treat without concern.


http://www.uninet.edu/cin2003/conf/mmoyses/mmoyses.html
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JoeReal
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Joined: 16 Nov 2005
Posts: 4726
Location: Davis, California

Posted: Wed 31 Jan, 2007 9:15 pm

This too:

http://www.kidney.ab.ca/kitchen/warnings.html

Grapefruit Warning

There is a growing body of evidence that shows grapefruit juice interacts with many of the medications that dialysis patients are prescribed.

DO NOT drink grapefruit juice if you take any of these medications. If you aren't sure if you take any of these medications, ask your doctor or pharmacist.

* Blood pressure lowering agents (calcium channel blockers)
* Persenadine
* Sedatives (benzodiazepines)
* Estrogens
* Quinidine
* Saquinavir
* Cholesterol lowering agents (statins)
* Cyclosporin (immunosuppressants)
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tomm
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Joined: 24 Feb 2006
Posts: 82
Location: Costa Mesa, Orange, CA Z10

Posted: Thu 01 Feb, 2007 1:21 am

Just two days ago, I experienced Star Fruit intoxication.
A few days ago, I cut a slice off a Star Fruit and it was
somewhat too acidic. I set it on the kitchen counter for a
few days to see if it would taste better then. It did.

I cut up the remaining 3/4 of the Star Fruit and enjoyed it
for desert after dinner, at about 7:00 PM. I went to bed as
usual shortly after 9:00 P.M. ...

A few minutes after 1:00 AM I woke up. I waited patiently,
expecting to fall asleep as usual, and noticed I was still
awake at 2:00 AM! So, I got up and visited the bathroom.
My urine looked normal. As far as I know, my kidneys
are working OK. Back to bed.

At 3:00, I noticed that I was staring out the window while
laying in bed. Rather than waste my time just laying there,
I got up and turned on the computer. I greatly enjoyed
reading Joe Real's postings with the cat resting in my lap.

Then I had to go to a class and I stayed awake without a
problem. I took a nap at 3:00 in the afternoon.

So there must be something in
Star Fruit (Averrhoa carambola )
that affects me like caffeine in Coffee.
I did not have any hiccups, the most frequent symptom
of Star Fruit intoxication or poisoning.

I agree with the articles that the active substance is not
Potassium or Oxalic Acid. Perhaps some unknown neurotoxin.

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Tom Mortell
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garnetmoth
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Joined: 28 Nov 2005
Posts: 440
Location: Cincinnati, OH

Posted: Thu 01 Feb, 2007 2:55 am

I had a week-long internship in a hemodialysis clinic in Santa Maria during my dietetic internship. My preceptor told me about this.

It is very important that those with any kidney dysfunction avoid the star fruit. ( most dialysis patients should strictly limit fresh fruit in general due to potassium content)


Grapefruit interferes with the metabolism of benzodiazepine drugs, increasing the effect (and possibly spurring an OD- quick internet search states effect can last 3 days). any effects of grapefruit or juice is for ANY people, not just those on dialysis.
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Nick in the UK
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Joined: 10 Apr 2006
Posts: 62
Location: UK

Posted: Fri 02 Feb, 2007 7:28 am

My partner had a Kidney transplant 3 months ago and has been told not to eat Grapefruit.

As a result she is on anti-rejections drugs and there is something in Grapefruit and possibly Starfruit that interferes with these drugs meaning it affects the levels of the drug in the body. If the levels are too low there is a high risk of rejection or failure of the new Kidney, if the levels are too high the drug is toxic to the Kidney and will damage it leading to rejection.

It's a balance of keeping the levels right, constantly reviewing the dose, but considered worth any risks to give someone a Kidney that will last from 3 months to 15 years and mean they get a break from dialysis and everything that goes with that.

So, I guess Starfruit may be the same.

Don't know if there is anything in Grapefruit or Starfruit causing Kidney failure. Haven't heard this one since she was diagnosed with Kidney failure or during the time she was on Dialysis.

Nick
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Nick in the UK
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Joined: 10 Apr 2006
Posts: 62
Location: UK

Posted: Fri 02 Feb, 2007 3:16 pm

Found this:-

'Star fruit originated in Southeast Asia and is readily available in Taiwan. Star fruit causes several symptoms in patients with chronic renal failure or end-stage renal disease. The symptoms vary and include insomnia, intractable hiccups, agitation, muscle weakness, confusion, consciousness disturbances of various degrees, seizures, and cardiorespiratory arrest. The various star fruit subspecies contain different toxins, including a powerful
neurotoxin that is suspected to accumulate in blood, cross the blood-brain barrier in chronic renal failure patients, and eventually cause irreversible damage.
Star fruit intoxication is a neglected but serious fruit intoxication frequently observed in patients with chronic renal failure. Because no effective treatment is currently available, patients— especially those who are newly diagnosed with chronic renal failure or end-stage renal disease—must be warned not to ingest star fruit, even in small amounts.'

I guess all this is because of what Renal failure does to the normal functioning of the body

I am trying a few contact to see if there is anything that clears up whether Grapefruit and Star Fruit actually cause or contribute to causing Kidney Failure

Nick
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