Discussing pros and cons here for California.
1) We have mostly alkaline soils, and if a person's diet is salty that could be a problem later.
2) The intent is to apply when fruit trees are dormant to kill off spores. This is during the winter when there is always a series of rains that can wash off and dilute these applications. The technique is timing of application. Apply during forecasted rainless days of early winter, for sure these will be washed off by rains in the later parts of winter. We don't want to apply and then to be washed off the next day.
3) In the context of stone and pome fruits, and applying during the winter, it is almost an impossibility to get E. Coli outbreaks in the harvested fruits, a long long time after whatever organic based stuff or urea fertilizers have been applied. If you have proper drainage and aeration, this should not be a problem.
4) But for foliar spray on vegetables, or direct application on fruits (ie citrus fruits) and other edible parts, this technique would be suicidal to use anytime of the year, for all the other factors you have mentioned.
5) If you are taking medications such as antibiotics, you will also be indirectly selecting for antibiotic resistant strains of microorganisms. This is happening already as we dump sewage into the rivers, ground water and oceans even if we treat them before dumping. It is just too expensive to remove these medicines and other chemicals from our waters, that even the precipitations in Antartica has been found to be contaminated.
just more to consider, am not taking sides.